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Many of you for certain heard about the editor of a genome of CRISPR thanks to whom already many discoveries were made. However, according to scientists from Stanford University, some people can have congenital immunity to "intervention" in our DNA that calls into question expediency of use of this technology.

"Our own immunity will prevent safe and effective application of CRISPR and can even even lead to serious toxic defeats of an organism. The type of protein of Cas9 most widespread for today is received from golden staphylococcus and a piogenny streptococcus. It can also explain that fact from where our organism has immunity to such young technology. Both of these bacteria attack the person for hundreds of years. However emergence of new CRISPR technologies can solve this problem, potential at editing a genome is simply huge".

During a series of experiments experts from Stanford investigated blood samples of 22 newborns and 12 adults for the purpose of detection of antibodies to Cas9. Let's remind that Cas9 is used for cutting of a spiral of DNA by means of what there is actually an editing. Experts found out that 65% of participants of an experiment have in T-cage blood (a cage of the immune system) which can protect DNA from influence of Cas9. Thus it is possible to draw a conclusion that "panacea" from genetic diseases can be inefficient at more than half of people. As one of authors of work Mathew Portyyus said in an interview to the bioRxiv edition,